Enabling homes to realise zero pollution holds multiple health benefits for all Europeans – especially our children. This is the goal of the EU-funded INQUIRE project. It will provide the knowledge, tools and measures needed to significantly enhance indoor air quality. Research on hazardous determinants and their sources, risk factors and effects will focus in particular on infants and young children up to 5 years old. The work will include non-invasive sampling and monitoring of over 200 homes in eight countries over the course of 1 month. Results will inform evidence-based recommendations and support beneficial exploitation by industry and policymakers.